Allergy Specialist & Immunologist
The first thing that stands out to me from this description is that it's plausible he could have had a reaction to the alpha-gal allergen present in ticks. This is an increasingly recognized cause of anaphylaxis, and it certainly would require him to continue to carry his epipen. It's possible that this allergy wanes over time, so if there was a sufficient amount of time in between the initial reaction and then subsequent tick bites, he may have lost the allergy. It's also increasingly recognised allergic reaction, and it tends to place patients at risk of mammalian meat allergy. There is a blood test available for this, which may be indicated based on specialist assessment. Ultimately I'd recommend that he see an allergist.
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