Yes, statistics show that there is a 40% chance is due to a female factor, 40% due to a male factor and 20% is unexplained. Interestingly in my clinic, I have found that it is mostly due to a male factor. Sperm are more vulnerable to toxicity because it takes about 116 days to make a new batch of sperm cells from scratch and during this time anything that is ingested, inhaled or absorbed through the skin, can affect the development of sperm. Also heat can affect sperm development so men need to wear boxer shorts (the loose ones) and avoid hot baths, spas and saunas. If they are overweight, then this will create more heat so they may need to lose weight.
Infertility due to a female factor is often due to tubal blockages which could be from scarring (due to a past sexually transmitted infection) or endometriosis (the endometrial tissue can block the tubes). Or it could be due to a hormone imbalance which causes a failure to ovulate or if she is in her late 30s or early 40s it could be due to declining egg quality.
It is possible that a woman is able to conceive but the fertilised egg fails to implant in her uterus - in fact, on average, out of 100 fertilised eggs, only 69 will implant in the uterus. Failure to implant could be due to a hormone imbalance - you need enough oestrogen to build a healthy endometrium to nourish the embryo and enough progesterone to sustain the pregnancy. Oestrogen also creates fertile mucus - this is the mucus which looks like raw egg white around the time of ovulation.
There is also the chance that it is the combination of both partners which is causing the infertility.
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