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  • Q&A with Australian Health Practitioners

    Can radioactive treatment cause Pagets disease?

    Related Topics
    Breast Cancer Cancer Osteoarthritis
    I have developed Pagets since removal of my thyroid and radioactive idiodine treatment for cancer.

    Do Endocrinologists treat Pagets? My breast cancer oncologist has suggested and endocrinologist but my GP thinks a rheumatoligist.

    Bone scans were normal 2 years ago when first diagnosed for both cancers but recent bone scan after x-rays showed fractures in my spine, and so diagnosed Pagets disease in my spine, facial bones and skull.

    Would the radioactive treatment have caused this?
    • 1 answer
    • Dr Simon Easterbrook-Smith
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  • Dr Simon Easterbrook-Smith

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    My research interests include immunology and the mechanisms of amyloid formation. The latter has implications for people who are dealing with Alzheimer's Disease, Parkinson's Disease … View Profile

    My understanding, based on a PubMed search, is that radiotherapy is not a risk factor for Paget's disease.
     
    I think that your GP and oncologist have both made sensible suggestions -  getting referral(s) to a rheumatologist and/or an endocrinologist is a good plan.
     
    You might find the information in this site helpful:
     
    http://www.mayoclinic.org/diseases-conditions/pagets-disease-of-bone/basics/definition/con-20020138

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