I have had a similar experience, although I changed in the end from SSRI to SNRI. I have tried Cymbalta in the past & exactly the same thing happened to me, positive changes for a bit and then it seemed to stop working. While I was on Cymbalta had really bad fatigue. Before trying SNRI's I was on Lexapro for 6 yrs or more. I didn't find it made things a lot better but it helped when I was taking the maximum dose. One good thing about it was it seemed to have way less side effects than others & didn't cause fatigue, although did cause increased sweating/night sweats. Have generally found SNRI's more helful with depression. Pristiq wasn't doing much for me at first, but since it's been increased up to 150mg is definetly better.
I have been really fatigued for years & was always getting constant colds/infections. A Dr checked my Vitamin D level & it was drastically low! This can cause or worsen depression, fatigue and also cause/worsen a lot of other health problems, as being low really affects your immune system. Ended up being put on a high dose of Vitamin D for months. Now my level is optimal, i've stopped getting colds/infections, feel less fatigued & has helped depression. Would definetly suggest asking to get yours checked if you are indoors a lot. Going out in the sun more has helped my mood too!
I've had major depression for more than a decade. Have found that it takes a real combination of approaches together to improve things. A supportive Psychologist who you develop trust with is probably the best thing. Medication helps as well. Having a good support network e.g helpful friends and family goes a long way. I didn't have this so joined groups on www.meetup.com Getting out to do fun, social things & meeting nice people, even when i felt the worst, has probably been the most helpful of all. Also, finding hobbies i enjoyed, especially ones with excercise like dancing has lifted my mood a lot.
Also noticed diet played a role in how bad or good i felt. Eating more of the healthy fats, like salmon fish, avocados, olive oil etc helps the brain, which helps medication work better. Eating bananas when your feeling low helps a little bit.
But yeah, I think it really takes a combination of approaches to help things. I hope you end up finding the right meds and that things improve for you :)
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