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The midfoot is the central part of the foot between the hindfoot and forefoot. It consists of multiple small joints, including the important Lisfranc joint, and forms the arch of the foot. Midfoot arthritis or inflammation of the midfoot joints can occur secondary to gradual degenerative wear of the cartilage (osteoarthritis), as a complication of previous trauma such as from a Lisfranc injury, or as a result of an inflammatory condition such as rheumatoid arthritis. The natural history of this condition is usually progression over time, but can be asymptomatic.