The best prenatal supplements are ones which contain vitamins in a bioavailable form. Basically this means your body does not have to “work hard' to convert it into a form it can use. Also, sometimes people are lacking the enzymes required to convert it into a bioavailable form, e.g. pyridoxine hydrochloride needs to be converted into pyridoxal-5-phosphate (the active form of B6) and if your body lacks the enzyme to convert it, then you will end up with expensive urine.
I don't like to use any prenatal supplements which contain B12 in the form of cyanocobalamin - this is cyanide attached to cobalamin which scientists say is safe in small doses but i'm personally not comfortable with any dose of cyanide during pregnancy.
A woman should have blood tests before taking any supplements, especially if they contain iron as although iron is required in higher amounts during pregnancy, there is a risk of toxicity if her levels were high to begin with - I like to check ferritin (iron stores) at the end of each trimester to assess what dose of iron she should be taking.
During the first trimester iron can contribute to nausea and in the second and third trimesters extra calcium and magnesium is usually required.
For all of the reasons above I prefer to use NaturoBest which has a separate formula for the first trimester of pregnancy to reduce morning sickness as well as providing high quality nutrients important at that stage of pregnancy.
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